Technical Data
H9110-17C
Hydroxyoctadecadienoic Acid 13(S) (HODE)
100ug
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Technical Data |
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H9110-17C |
Hydroxyoctadecadienoic Acid 13(S) (HODE) |
100ug |
| Biochemicals | Storage: -20°CShipping: RT |
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13(S)-HODE (13(S)-hydroxyoctadecadienoic acid) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells. The biological effects of 13(S)-HODE include inhibition of tumor cell adhesion to the endothelium at concentrations around 1uM,1,2 and down regulation of IRGpIIb/IIIa receptor expression.3 13(S)-HODE methyl ester is a neutral, more lipophilic form of the free acid that can been used as an analytical standard for 13(S)-HODE. Purity: 98% Form: Supplied as a solution in ethanol Stability: 1 year at -20°C Molecular Formula: C19H34O3 Molecular Weight: 310.5 |
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1 Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. J Biol Chem 260 16056-16059 (1985). 2 Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44 413-429 (1992). 3 Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49 1029-1037 (1989).
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