Technical Data
21-hydroxyoligomycin A (Nemadectin omega, Antibiotic LL-F28249 omega)
Biochemicals Storage: -20CShipping: Blue Ice
21-Hydroxyoligomycin A is a rare member of the oligomycin class isolated as a co-metabolite of nemadectin, hence its original naming as nemadectin omega. Only limited literature references to this metabolite are available. However, in-house testing suggests that 21-hydroxyoligomycin has a more selective action against mammalian tumor cell lines than oligomycin A, exhibiting only weak antifungal and nematocidal activity.

Soluble in ethanol, methanol, DMF or DMSO.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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Source: Streptomyces sp.
Form: Supplied as a white lyophillized powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Structure and Absolute Stereochemistry of 21-Hydroxyoligomycin A. Wagenaar M.M. et al. J. Nat. Prod. 2007, in press.
2. Plasmid effects on secondary metabolite production by a streptomycete synthesizing an anthelmintic macrolide.Thomas D.I. et al. J. Gen. Microbiol. 1991, 137, 2331.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.