Technical Data
H9130-04
10-Hydroxy Warfarin (4-Hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1-benzopryan-2-one)
5mg
Biochemicals Storage: -20CShipping: RT
A major CYP3A4 metabolite of R-Warfarin.

Warfarin (also known under the brand names Coumadin, Jantoven, Marevan, Lawarin, Waran, and Warfant) is ananticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. Warfarin was found to be effective and relatively safe for preventing thrombosis andembolism (abnormal formation and migration of blood clots) in many disorders. Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K, but rather antagonizes vitamin K recycling, depleting active vitamin K. Thus, the pharmacologic action may always be reversed by fresh vitamin K. Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant. The name warfarin stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization which funded the key research (WARF, for Wisconsin Alumni Research Foundation) and the ending -arin,indicating its link with coumarin.

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Formula:
C19H16O5
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.