Technical Data
I2300-20
Ikarugamycin
500ug
Biochemicals Storage: -20CShipping: Blue Ice
Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful
agent for studying the process of endocytosis.

Source: Streptomyces sp.

Apperance: White solid

Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
36531-78-9

Molecular Formula:
C29H38N2O4

Molecular Weight:
478.6
Source: Streptomyces sp.
Purity: ~99%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. A new antibiotic, ikarugamycin. Jomom K. et al., J. Antibiot. 1972, 25, 271. 2. Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycin. Hasumi K. et al., Eur. J. Biochem. 1992, 205, 841. 3. Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin. Luo T. et al., J. Virol. 2001, 75, 2488. 4. Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold. Moscatelli A. et al., J. Cell Sci. 2007, 120, 3804.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.