Technical Data
I7652-54
ING1 (Inhibitor of Growth 1, Growth Inhibitory Protein ING1, Inhibitor of Growth Family Member 1, p24ING1c, p33 ING1, p33ING1b, p47, p47ING1a, Tumor Suppressor ING1)
Description:
The p33ING1 protein encodes a 33-kD, 294-amino acid protein that displays the characteristics of a tumor suppressor gene. The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. It can mediate growth arrest, anchor dependent growth and influence hemosensitivity (1-4). It also has a proposed role as a growth regulator, which is consistent with its location in
the nucleus (5). It has been demonstrated that the ING1 gene has three exons and that four mRNA variants are transcribed from three different promoter regions (p33 ING1, p24 ING1,
p27 ING1, p47 IG1) (6, 7). ING1 can possibly influence the above biological functions depending on which variant is expressed (1-4).

Applications:
Suitable for use in RIA, Immunofluorescence, ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 250ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
400ul-20CBlue IceMouseRabbit
Concentration:
~0.25mg/ml
Immunogen:
Mouse p33 ING1 N-terminal peptide KLH conjugates.
Purity:
Serum.
Form
Supplied as a liquid in TBS, 0.1%NaN3.
Specificity:
Recognizes mouse p33 ING1. Species cross-Reactivity: human(1).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Cheung, K.J., Jr. and Li, G. (2002) Int. J.Oncol. 21(6):1361-1365. 2. Cheung, K.J., Jr. and Li, G. (2002) Exp. Cell Res. 279(2):291-28. 3. Cheung, K.J., Jr. and Li, G. (2002) Int. J Oncol. 20(6):1319-1322. 4. Cheung, K.J., Jr. and Li, G. (2001) Exp. Cell Res. 268(1):1-6. 5. Garkavtsev, I. et al. (1996). Nat Genet. 14 (4):415-420. 6. Gunduz, M. et al. (2000). Cancer Res. 60(12): 3143-6. 7. Jager, D. et al. (1999). Cancer Res. 59: 6197-6204.