Technical Data
I7661-44
Integrin beta6
Description:
Integrins are a large family of transmembrane proteins composed of an alpha and beta component. Integrins are involved in a diversity of biological functions such as cell adhesion, structure, differentiation, apoptosis and cell proliferation. They are the principal cell surface receptors that recognize cell to matrix interactions, but little is known about the expression of beta 1 integrin family on airway smooth muscle (ASM) and their involvement in proliferation. This is a contributing factor in structural changes seen in asthma.

Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Not suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilutions:
Flow Cytometry: Effective for all species tested.
Immunohistochemistry: Acetone fixation. Effective for rabbit, rat, monkey and human. Not suitable for use on mouse tissue.
Immunocytochemistry: Effective for F6, HT-29, H441 cell lines.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG12Q790Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Immunization of beta6 knockout mice with recombinant secreted human alphaVbeta6. Epitope: Unknown whether the epitope recognized by the antibody localizes to the alphaVbeta6 heterodimer or to the beta6 subunit only.
Purity:
Purified
Form
Supplied as a liquid in PBS. No preservatives added.
Specificity:
Recognizes human Integrin alphaVbeta6. Does not recognize the alphaV subunit. Does not recognize alphaV integrins other than alphaVbeta6. Species Crossreactivity: rabbit, rat, monkey and mouse (not IHC).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.