Technical Data
I7662-10P
Interferon Beta (IFN-beta, Ifnb1, Ifb, Ifnb)
Description:
interferon beta (IFN Beta), a 22kD cytokine with wide-ranging antiviral, antimicrobial and antitumor effects. Interferons also serve to activate macrophages, natural killer cells and the presentation of antigens to the immune system by the major histocompatibility complex. The production of interferon is induced in response to microbes and other cytokines. The interferons are widely used to treat a variety of diseases and IFNB in particular is used to treat relapsing-remitting multiple sclerosis.

Applications:
Suitable for use in Neutralization, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
20KU-20CBlue IceMouseRabbit
Concentration:
As reported
Immunogen:
Recombinant corresponding to mouse interferon beta expressed in E.coli.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in 0.3M NaHCO3, 0.2M sodium chloride.
Specificity:
Recognizes mouse interferon beta.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Asselin-Paturel et al. (J Exp. Med, 2005) used 32400 in combination with Rabbit mouse IFN-alpha (32100) to explore the role of Type I IFN in the migration and activation of dendritic cells. Kamath et al. (J. Immunol. 2005) used a similar cocktail to demonstrate that dendritic cell derived Type I IFN stimulates bystander T-cells. 2. Seimon et al. (P.N.A.S, 2006) used 32400 to examine the role of IFN-Beta in protecting LPS treated macrophages from apoptosis. Zheng et al. (J. Biol. Chem, 2006) used 32400 to examine the role of autocrine IFN-Beta in RANKL stimulated iNOS expression in macrophages.