Technical Data
I7662-86E
Interferon Regulatory Factor 3 (IRF3)
Description:
IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabSerum
SizeStorageShippingSourceHost
100ul-20°CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
A synthetic peptide that maps to a region between residues 100 and 150 of human Interferon Regulatory Factor 3 using the numbering given in Swiss-Prot entry Q14653 (GeneID 3661).
Purity:
Serum
Form
As reported
Specificity:
Specific for human IRF3 protein. Other species not tested. Reactivity with mouse is possible owing to moderate conservation of sequence between this ortholog and human IRF3 at the site to which the epitope maps.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.