Technical Data
I7663-25N3
Interleukin 1 Receptor Antagonist, Recombinant, Human (IL-1RA)
50ug
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Technical Data |
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I7663-25N3 |
Interleukin 1 Receptor Antagonist, Recombinant, Human (IL-1RA) |
50ug |
| Growth Factors, Cytokines | Storage: -20°CShipping: Blue Ice |
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One of the most potent pro-inflammatory mediators is the early-acting cytokine interleukin-1 (IL-1), whose actions are regulated by the structurally related IL-1 receptor antagonist (IL-1 RA). IL-1 RA is a competitive IL-1 inhibitor and a powerful anti-inflammatory agent. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1 RA gene. Recombinant human IL-1 RA was expressed in E. coli and consists of 153 amino acids. AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Molecular Weight: 17.2kD |
Source: Human, Recombinant, E. coli Purity: ~95% by SDS-PAGE. Purified by using conventional chromatography techniques. Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, pH 7.4. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Capper, et al. Clin. Exp. Immunol. 138: 348 (2004). 2. Roberge, C.J., et al., Journal of Immunology 152: 5485-5494 (1994). 3. Carter, D.B., et al., Nature 344: 633-637 (1990).
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