		Technical Data
I7663-61	Interleukin 1 Receptor Antagonist (IL-1RA)

Description:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Applications:
Suitable for use in Immunohistochemistry, ELISA and Chemiluminescent Immuno Assay (CLIA). Other applications not tested.

Recommended Dilution:
Immunohistochemistry: Frozen
ELISA: 20-2000pg/ml
CLIA: 0.050-15ng/ml
Optimal dilution to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG1	4H145	Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Mouse

Concentration:

1mg/ml

Immunogen:

Human IL-1RA

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.1% sodium azide.

Specificity:

Recognizes both the recombinant and the natural form of human IL-1RA.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Andersson J, J Abrams, L Bjork, K Funa, M Litton, K Agren, U Andersson. Immunology 83:16-24 (1994). 2. Raqib R, AA Lindberg, B Wretlind, PK Bardhan, U Andersson, J Andersson. Infection Immunity 63:289-296. et al. Infection and Immunity, 63:289-296 (1995).