Technical Data
IL1RA, Recombinant, Mouse (IL-1RA, Interleukin Receptor 1RA, Interleukin-1 Receptor Antagonist Protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 Inhibitor, Anakinra, IL1F3, IL1RN)
Molecular Biology Storage: -20CShipping: Blue Ice
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 153aa and having a molecular mass of 17.4kD. The IL1RA is purified by proprietary chromatographic techniques

Recombinant corresponding to mouse IL-1RA expressed in E. coli.

AA Sequence:
be Ala-Cys-Arg-Pro-Ser-Gly

Molecular Weight:

Biological Activity:
The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
Source: E. coli
Purity: ~98% (SDS-PAGE)
Concentration: Not determined
Form: Supplied as a lyophilized powder from H2O, sodium bicarbonate. Reconstitute with sterile dH2O to 100ug/ml.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.