Technical Data
I8432-01T
Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)
100ug
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Technical Data |
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I8432-01T |
Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) |
100ug |
| Growth Factors, Cytokines | Storage: -20°CShipping: Blue Ice |
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Interleukin-10 (IL 10) is also known as human cytokine synthesis inhibitory factor (CSIF) and inhibits the synthesis of pro-inflammatory cytokines like IFN-gamma, IL2, IL3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. This protein has effects in immunoregulation and inflammation and down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. Recombinant IL10 protein, fused to His-tag at N-terminus, was expressed in E. coli and was purified by conventional chromatography techniques. Source: Human, His-tagged, Recombinant, E. coli, 19-178aa AA Sequence: MGSSHHHHHH SSGLVPRGSH MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N Endotoxin Level: 1.0 EU/1ug (LAL). Storage and Stability: Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Molecular Weight: 20.94kD |
Source: E. coli Purity: Purified 95% by SDS-PAGE. Concentration: ~0.5mg/ml Form: Supplied as a liquid in 20mm Tris-HCl buffer, pH 8.0, 20% glycerol. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Moore KW., et al. (2001). Annu. Rev.Immunol. 19: 683-765 2. Mocellin S., et al. (2004). Trends Immunol. 24 (1): 36–43.
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