Technical Data
Interleukin 13 (IL-13)
IL-13 is an immunoregulatory cytokine produced mainly by T helper 2 cells, but also by mast cells and NK cells. IL-13 is a unique cytokine having structural features and functional characteristics with IL-4. However, it only shares about 30% homology with the IL-4 sequence. IL-13 inhibits IL-1 beta, IL-6, IL-8, and TNF-alpha resulting in anti-in ammatory effects on monocytes and macrophages. It also induces B cells to proliferate and isotype-switch to the production of IgE. In addition, IL-13 modulates TH2 cell development interfering key roles in the ostracizing of gastrointestinal parasites and in the evolvement of asthma and allergy.

Suitable for use in Neutralizing, ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Western Blot: 5ug/ml. Detects 100ng of human IL-13
Immunohistochemistry: Frozen sections
Note: Further dilutions should be made in in medium or buffered solutions with a carrier protein such as 1% BSA.
Optimal dilutions to be determined by researcher.

Rat spleen cells fused with P3X63-AG8.653 myeloma

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG11.B2.1Affinity Purified
100ug-20°CBlue IceHumanRat
Purified recombinant human IL-13
Purified by Protein A/G affinity chromatography.
Supplied as a liquid in PBS.
Recognizes natural and recombinant human IL-13.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Pawanakar, R.U., et al., Amer. J. Resp. Critical Care Med. 152: 2059-2067 (1995). 2. Prussin C, Metcalf D., I. Immunol. Meth. 188: 117-128 (1995).