Technical Data
I8439-36
Interleukin-17 Receptor A (IL17RA, IL-17RA, CDw217, CD217, MGC10262, AW538159) (APC)
Description:
IL-17R, also known as IL-17RA, is a widely expressed 120kD glycosylated type I protein that plays a central role in inflammatory responses. IL-17R associates with IL-17RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17R shares 72% aa sequence identity with mouse and rat IL-17R.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:8000
Western Blot: 1-3ug/ml detects an ~10kDa band observed in Rat Kidney lysates (calculated MW of 96.1kDa according to Mouse NP_032385.1 and of 97.9kDa according to Rat NP_001101353.2).
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceRatGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to C-DQEKHGDDSKIN, from the internal region of rat IL17ra (NP_032385.1).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Specificity:
Recognizes rat IL17ra. Species sequence homology: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Gaffen SL, Kramer JM, Yu JJ, Shen F. The IL-17 cytokine family. Vitam Horm. 2006;74:255-82. Review. PMID: 17027518.