		Technical Data
I8439-36	IL17ra (Interleukin 17 receptor A, AW538159, Cdw217, IL17r, VDw217, Interleukin 17 receptor)

Description:
IL-17R, also known as IL-17RA, is a widely expressed 120kD glycosylated type I protein that plays a central role in inflammatory responses. IL-17R associates with IL-17RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17R shares 72% aa sequence identity with mouse and rat IL-17R.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:8000
Western Blot: 1-3ug/ml detects an ~10kDa band observed in Rat Kidney lysates (calculated MW of 96.1kDa according to Mouse NP_032385.1 and of 97.9kDa according to Rat NP_001101353.2).
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Rat	Goat

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to C-DQEKHGDDSKIN, from the internal region of rat IL17ra (NP_032385.1).

Purity:

Purified by affinity chromatography.

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

Specificity:

Recognizes rat IL17ra. Species sequence homology: mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Gaffen SL, Kramer JM, Yu JJ, Shen F. The IL-17 cytokine family. Vitam Horm. 2006;74:255-82. Review. PMID: 17027518.