Technical Data
I8442-22
Interleukin 21 Receptor (IL-21R)
Description:
A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling (3,4). Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

Applications:
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
ELISA (peptide): 1:100,000
Immunohistochemistry: 1:300
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to aa 35-46, CVLETRSPNPSIL SLTWQDEYEELQDQETF of mouse IL-21 receptor.
Purity:
Purified by Immunoffinity chromatography.
Form
Supplied as a liquid in PBS, 1mg/ml BSA, 0.1% sodium azide.
Specificity:
Recognizes N-terminus of mouse IL-21 receptor.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain: K. Ozaki, et al.; PNAS 97, 11439 (2000)