Technical Data
I8442-42
IL-32 (Interleukin-32, Natural Killer Cells Protein 4, Tumor Necrosis Factor alpha-inducing Factor, IL32, NK4, TAIF)
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Technical Data |
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I8442-42 |
IL-32 (Interleukin-32, Natural Killer Cells Protein 4, Tumor Necrosis Factor alpha-inducing Factor, IL32, NK4, TAIF) |
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Description: IL-32 is a 234aa protein belonging to the cytokine family and contains a tyrosine sulfation site, three potential N-myristoylation sites, multiple putative phosphorylation sites and an RGD cell-attachment sequence. It plays a role in activation-induced cell death in T cells, production of TNFalpha from macrophage cells and in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL-8 and activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. IL-32 appears to play a role in the pathogenesis of human rheumatoid arthritis and is a novel target in autoimmune diseases. It is expressed predominantly in lymphocytes and immune cells. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2.5-5ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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