Technical Data
I8442-42P
IL-32 (Interleukin-32, Natural Killer Cells Protein 4, Tumor Necrosis Factor alpha-inducing Factor, IL32, NK4, TAIF)
Description:
IL-32 is a 234aa protein belonging to the cytokine family and contains a tyrosine sulfation site, three potential N-myristoylation sites, multiple putative phosphorylation sites and an RGD cell-attachment sequence. It plays a role in activation-induced cell death in T cells, production of TNFalpha from macrophage cells and in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL-8 and activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. IL-32 appears to play a role in the pathogenesis of human rheumatoid arthritis and is a novel target in autoimmune diseases. It is expressed predominantly in lymphocytes and immune cells.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa208-225 (SFQSYGAPRGDKEELTPQ) of human IL-32.
Purity:
Serum
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human IL-32.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Goda, C. et al. Int. Immunol. 18:233-240 (2006). 2. Joosten, LA. et al. Proc. Natl. Acad. Sci. USA. 103:3298-3303 (2006).