Technical Data
I8442-42R
IL-32 (Interleukin-32, Natural Killer Cells Protein 4, Tumor Necrosis Factor alpha-inducing Factor, IL32, NK4, TAIF)
Description:
IL-32 is the name given to the NK4 transcript first reported in IL-2 activated T lymphocytes and natural killer cells. IL-32 induces the degradation of inhibitory kappaB and phosphorylation of mitogen activated protein p38 and has a possible role in inflammatory:autoimmune diseases like chronic obstructive pulmonary disease, Crohn's disease and psoriasis. The protein activates typical cytokine signal pathways of nuclear factor-kappa B (NF-kappaB) and p38 mitogen-activated protein kinase. The protein contains a tyrosine sulfation site, three potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. It is selectively expressed in human lymphocytes. The gene encoding human IL-32 protein is localized on chromosome 16p13.3.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide PELTPLLEKERDGLRC.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity:
Recognizes human Interleukin 32.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Dahl,C.A., Schall,R.P., He,H.L. and Cairns,J.S. Identification of a novel gene expressed in activated natural killer cells and T cells J. Immunol. 148 (2), 597-603 (1992).