Technical Data
I8442-76
Internexin, alpha, CT
Description:
alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage.

Application(s):
Immunohistochemistry on formalin or paraformaldehyde fixed tissues. Immunocytochemistry on NTera2 and PC12 cells.
Western blot
ELISA
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
50ul-20CBlue IceRatRabbit
Concentration:
Not determined
Immunogen:
Full length recombinant rat a-internexin fused to E. coli Trp E
Purity:
Serum
Form
Supplied as a lyophilized powder, containing no preservatives.(Reconsititute with 500ml of sterile distilled water)
Specificity:
Recognizes human, rat, bovine, porcine, mouse and feline internexin, C-terminal globular tail region.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Evans, J., et al., J. Neurophysiol. (2002) 87:10761085.