		Technical Data
I8443-49H	IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

Description:
IL-23R is a novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12 receptor beta 1 and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Serum

Size		Storage	Shipping	Source	Host
100ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

Not determined.

Immunogen:

Synthetic peptide corresponding to aa253-273(CEMRYKATTNQTWNVKEFDTN) of human IL-23R.

Purity:

Serum

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

Specificity:

Recognizes human IL-23 Receptor. Species Crossreactivity: chimpanzee, equine, rat. Species sequence homology: bovine, canine, monkey, mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Cargill, M. et al. Am. J. Hum. Genet. 80:273-290 (2007). 2. Duerr, R. et al. Science. 314:1461-1463 (2006). 3. Zhang, XY. et al. Immunogenetics. 57:934-943 (2006).