Technical Data
I8449-06A
IP-10 (Interferon gamma Inducible 10kD Protein, Chemokine CXC Motif Ligand 10, CXCL10, CRG2)
Description:
Interferon-gamma-inducible 10kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis.

Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunofluoresence and ELISA. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:50
Western Blot: 1:50
Immunohistochemistry (frozen): 1:50
Optimal dilutions to be determined by the researcher.

Positive Control: Activated plasmacytoid dendritic cells

Negative Control: Normal liver

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a6A585Affinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
~0.1mg/ml
Immunogen:
Human IP-10.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
Specificity:
Recognizes human IP-10.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.