Technical Data
I8449-10C
IP-10, Mouse, Recombinant
5ug
25ug
100ug
25ug
100ug
|
Technical Data |
|
I8449-10C |
IP-10, Mouse, Recombinant |
5ug 25ug 100ug |
| Growth Factors, Cytokines | Storage: -70°CShipping: Blue Ice |
|
CXCL10, a CXC chemokine, has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease and Type 1 diabetes mellitus. The chemokine IP-10 (interferon-inducible protein of 10kD, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. Recombinant mouse IP-10 is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.7kD. Biological Activity: Murine IP-10 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract IL-2 activated T cells at 0.1-10ng/ml. AA Sequence: IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Molecular Weight: 8.7kD |
Source: Recombinant, murine, E. coli Purity: 97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Endotoxin: 0.1EU/ug (0.01ng/ug, LAL) Form: Supplied as a lyophilized powder. Reconstitute with sterile dH2O, 0.1% BSA or HSA to 0.1mg/ml, which can be further diluted into other aqueous solutions. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
|
1. Pediatr. Res. 61(1): 93-98 (2007). 2. J. Vasc. Res. 44(1): 51-60 (2007). 3. Hepatology 44(6): 1617-1625 (2006). 4. J. Interferon Cytokine Res. 26(10): 699-705 (2006). 5. J. Leukoc. Biol. 80(6): 1364-1374 (2006). 6. Circulation 114(12): 1293-1300 (2006).
|
||