Technical Data
I8565
IQ-1 (2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide)
1mg
Biochemicals Storage: 4CShipping: Blue Ice
Cell-permeable. Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents -catenin from switching coactivator usage from CBP to p300. The increase in -cateinin/CBP mediated transcription at the expense of - cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency.

Storage and Stability:
Lyophilized powder may be stored at 4C. Stable for 12 months at 4C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4C. Reconstituted product is stable for 6 months at 4C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
331001-62-8

Molecular Formula:
C21H22N4O2

Molecular Weight:
362.42D
Purity: ~95% (HPLC)
Form: Supplied as an orange solid. Reconstitute with DMSO.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Miyabashi, T., et al. (2007). Proc. Natl. Acad. Sci. USA 104, 5668.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.