Technical Data
IDE, ID (Insulin-degrading Enzyme, Insulysin, Insulinase, Insulin Protease, Abeta-Degrading Protease)
IDE belongs to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.

Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
200ul-20CBlue IceHumanRabbit
As reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 406-435 in the central region of human IDE, UniProt Accession #NP_004960; P14735. Species sequence homology: bovine, mouse, rat
Purified by ammonium sulfate precipitation.
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human IDE.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Vepsalainen,S.,J. Med. Genet. 44(9), 606-608 (2007). 2. Kim,M.,J. Biol. Chem. 282(11), 7825-7832 (2007). 3. Radulescu,R.T.,Int. J. Oncol. 30(1), 73-80 (2007). 4. Li,Q.,Cell 127(2), 305-316 (2006). 5. Razvan T. Radulescu, et al. Mol. Cancer Ther. published 13 October 2009, 10.1158/1535-7163.MCT-09-0706. (Applications: IP) (E-pub).