Technical Data
K0005-08B
Kallikrein 5 (Kallikrein-5, KLK5, Kallikrein-like Protein 2, KLKL2, KLK-L2, Kallikrein-related Peptidase 5, Stratum Corneum Tryptic Enzyme, SCTE, UNQ570/PRO1132)
Description:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK5 expression is up-regulated by estrogens and progestins. The protein is secreted and may be involved in desquamation in the epidermis.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide composed of corresponding to a portion of amino acids within aa152-181from the central region of human KLK5 (KLH).
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human KLK5.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Planque, C., et al., Biochem. Biophys. Res. Commun. 329(4):1260-1266 (2005). 2.Michael, I.P., et al., J. Biol. Chem. 280(15):14628-14635 (2005). 3.Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124(2):360-366 (2005). 4.Brattsand, M., et al., J. Invest. Dermatol. 124(1):198-203 (2005). 5.Caubet, C., et al., J. Invest. Dermatol. 122(5):1235-1244 (2004).