Technical Data
Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 )
Biochemicals Storage: -20CShipping: Blue Ice
Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.

Purity: >95% by HPLC

Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.

Related to: Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin A

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Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the
human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Wolff B. et al.
Chem. Biol. 1997, 4, 139.
2. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. Takamiya K.
et al. J. Antibiot. 1988, 41, 1854.
3. PD 124,895 and PD 124,966, two new antitumor antibiotics. Hurley T.R. et al. J. Antibiot. 1986, 39,

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.