Technical Data
K0292
3-Keto-N-aminoethyl-N-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)
250ug
Biochemicals Storage: -20CShipping: RT
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells.

Solubility:
As reported

Melting Point:
As reported

Atmosphere:
Inert gas

Method for Determining Identity: Proton NMR (CD30D) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions:
As reported

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Light, temperature and moisture sensitive. Solutions are not stable.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards:
All products should be handled by qualified personnel only, trained in laboratory procedures.

CAS Number:
306387-90-6

Molecular Formula:
C44H63N3O4

Molecular Weight:
697.99
Source: Synthetic
Purity: ~90%
Form: As reported

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.