Technical Data
KIF1B (Kinesin Family Member 1B, Charcot Marie Tooth Neuropathy 2A, CMT2A, CMT2A1, D4Mil1e, HMSNII, Hereditary Motor Sensory Neuropathy II, KIF1B p130, KIF1B p204, Kinesin-like Protein KIF1B, KLP)
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles,
vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36.2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms, a 7.8 kb mRNA encoding a 130kD protein, and a 10 kb mRNA encoding a 204kD protein.

Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabAffinity Purified
100ul-20CBlue IceHumanRabbit
The epitope recognized by this antibody maps to a region between residue 1575 and 1625 of human kinesin family member 1B using the numbering given in entry CAC16629.1 (GeneID 23095).
Purified by immunoaffinity chromatography.
Supplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.09% sodium azide.
Species Crossreactivity: Human and Mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.