Technical Data
K1759-25
KIF5C (Kinesin Family Member 5C, Kinesin 5C, FLJ44735, KIAA0531, Kinesin Heavy Chain Neuron Specific 2, KINN, MGC111478, NKHC, NKHC2)
Description:
Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure including a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. There are currently three known Kinesin 5 family members denoted as A, B, and C. Kinesin 5A and kinesin 5C appear to be exclusively neuronal, whereas kinesin 5B appears to be ubiquitous in its expression.

Cellular Localization: Cytoplasmic

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide: AVHAIRGGGGSSSNSTHYQK, corresponding to amino acids 938-957 of Human Kinesin 5C.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.05% sodium azide.
Specificity:
This antibody is specific for kinesin 5C and does not detect other kinesin isotypes. Species Crossreactivity: Crossreacts with Human. Does not crossreact with bovine or Mouse. Expected to crossreact with Rat (90% identity with immunogen) due to sequence homology. Not yet tested in other species.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.