Technical Data
LAG-1 (Lymphocyte activation gene-1 protein, CCL4L1)
Molecular Biology Storage: -20CShipping: RT
Lymphocyte activation gene-1 protein (LAG-1) ia a CC chemokine and is part of the MIP-1 beta family. LAG-1 is identical to MIP-beta (ACTII isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. Like MIP-1 beta, it shows in ammatory and chemokinetic properties. Lag-1 binds to both CCR5 and to CCR8. Studies have shown that LAG-1 plays an essential role in HIV suppressive factors. Recombinant Human LAG-1 is a 7.7kDa protein containing 69 amino acid residues.

Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20C. Reconstituted LAG-1 should be stored in working aliquots at -20C.

Purity: 98% by SDS-PAGE and HPLC analyses

Endotoxin: 0.1ng/ug (1EU/ug)

Reconstitution: We recommend a quick spin followed by reconstitution in water to a concentration of 0.11.0 mg/ml. This solution can then be diluted into other buffers and stored at 4C for 1 week or stored at -20C for future use.

Biological Activity: Determined by its ability to chemoattract CCR5 transfected cells using a concentration of 0.110.0ng/ml


Country of Origin: USA
Source: E. coli
Form: The sterile ltered solution was lyophilized with no additives.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.