Technical Data
L2601-02F
Lipoprotein Receptor, Low Density (Low-density Lipoprotein Receptor, LDL Receptor, LDLR, Familial Hypercholesterolemia, FH, FHC, LDLCQ2)
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Technical Data |
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L2601-02F |
Lipoprotein Receptor, Low Density (Low-density Lipoprotein Receptor, LDL Receptor, LDLR, Familial Hypercholesterolemia, FH, FHC, LDLCQ2) |
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Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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