Technical Data
L2601-04D
low density lipoprotein receptor-related protein 4 (LRP4, KIAA0816, LRP10, MEGF7, low-density lipoprotein receptor-related protein 4)
Description:
Low-density lipoprotein receptor-related protein 4 (LRP-4) is a novel, single-pass type I membrane protein belonging to the LDLR family and is comprised of three EGF-like domains, eight LDL-receptor class A domains, and twenty LDL-receptor class B repeats. The exact function of LRP-4 has yet to be elucidated, however it is thought to function as a cell surface receptor with the ability to both bind and neutralize extracellular ligands, internalizing them for lysosomal degradation. Expression has been observed in various regions of the brain.

Applications:
Suitable for use in Immunohistochemistry. Other applications have not been tested.

Recommended Dilutions:
Immunohistochemistry: 1:500 detects LRP-4 in normal human brain tissue.
Optimal dilutions to be determined by the researcher.

Positive Control:
Normal human brain tissue

Molecular Weight:
212 kDa calculated. It has been reported that transfection of LRP-4 reveals different protein products at 20 kDa, 75 kDa and 250 kDa. While the 250 kDa band represents full length LRP-4, the two smaller bands appear to be processing products of the receptor. No bands were detected in the untransfected conditions. (Dietrich, M.F., et al. (2010). PLoS ONE 5(4):e9960:1-7.)

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Linear peptide corresponding to human LRP-4 at the cytoplasmic domain (KLH).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity:
Recognizes human LRP-4. Species crossreactivity: mouse. Species sequence homology: rhesus monkey, ox, equine: 100%, rat: 92%.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.