Technical Data
L3220-50C
LNK (Lymphocyte Adapter Protein, Lymphocyte Specific Adapter Protein Lnk, SH2B Adaptor Protein 3, SH2B3, Signal Transduction Protein Lnk)
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Technical Data |
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L3220-50C |
LNK (Lymphocyte Adapter Protein, Lymphocyte Specific Adapter Protein Lnk, SH2B Adaptor Protein 3, SH2B3, Signal Transduction Protein Lnk) |
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Description: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:64,000 Western Blot: 0.3-1ug/ml detects ~70kD band observed in lysates of cell line MOLT4 (calculated MW of 63.2kD according to NP_005466.1). In transfected HEK293 transiently expressing SH2B3 a band of approx. 65kD is observed. This band is not observed in the non-transfected HEK293. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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