Technical Data
LOX1 (LOX-1, hLOX-1, C-type Lectin Domain Family 8 Member A, CLEC8A, Lectin-like Oxidized LDL Receptor 1, Lectin-like oxLDL Receptor 1, Lectin-type Oxidized LDL Receptor 1, LOXIN, Oxidized Low-density Lipoprotein Receptor 1, Ox-LDL Receptor 1, OLR1, SCARE
LOX-1 is a receptor for oxidized low-density lipoproteins (LDL). This receptor mediates the recognition, internalization and degradation of oxidized LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognizes the ligand. LOX-1 activation by oxidized LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by pro-atherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis.

Suitable for use in ELISA and Immunofluorescence. Other applications not tested.

Recommended Dilutions:
Immunofluorescence: 1:100-1:200. Fixation with 4% paraformaldehyde or methanol is recommended.
Optimal dilutions to be determined by the researcher.

Recommended Secondary Antibodies:
I1903-30H: IgG, H&L, X-adsorbed (FITC) Pab Sh xRb
I1903-30T: IgG, H&L, X-adsorbed (Biotin) Pab Sh xRb
I1903-30U: IgG, H&L, X-adsorbed (HRP) Pab Sh xRb

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
100ul-20CBlue IceHumanRabbit
Not Determined
Peptide corresponding to the C-terminal (extracellular) region of human LOX-1.
Supplied as a liquid, 0.09% sodium azide.
Recognizes the extracellular domain of human LOX-1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Chen, M. et al. (2002) LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol. Ther. 95: 89-100. 2. Li, D. et al. (2003) LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Atherosclerosis, Thrombosis and Vascular Biology 23: 816-821. 3. Morawietz, H. et al. (1999) Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Circulation 100: 899-902. 4. Sawamura, T. et al. (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-77. 5. Yoshida, H. et al. (1998) Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem. J. 334: 9-13.