		Technical Data
L4500-03G1	LRP, CT (Major Vault Protein, Lung Resistance-related Protein, MVP)

Description:
MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
200ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the C-terminal region of human MVP (KLH).

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human MVP.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.Aronica, E., et al., Epilepsia 44(9):1166-1175 (2003). 2.Klunder, J.W., et al., Hum. Pathol. 34(2):150-155 (2003). 3.Burger, H., et al., Clin. Cancer Res. 9(2):827-836 (2003). 4.Yu, Z., et al., J. Biol. Chem. 277(43):40247-40252 (2002). 5.van den Heuvel-Eibrink, M.M., et al., Leukemia 16(5):833-839 (2002).