Technical Data
L4500-03G1
LRP, CT (Major Vault Protein, Lung Resistance-related Protein, MVP)
Description:
MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the C-terminal region of human MVP (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human MVP.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Aronica, E., et al., Epilepsia 44(9):1166-1175 (2003). 2.Klunder, J.W., et al., Hum. Pathol. 34(2):150-155 (2003). 3.Burger, H., et al., Clin. Cancer Res. 9(2):827-836 (2003). 4.Yu, Z., et al., J. Biol. Chem. 277(43):40247-40252 (2002). 5.van den Heuvel-Eibrink, M.M., et al., Leukemia 16(5):833-839 (2002).