Technical Data
L4500-07
LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)
Description:
Applications:
Suitable for use in Flow Cytometry (cell permeabilization required with 10% lysing solution), Immunostaining of cytospin preparations and Immunohistochemistry (cell suspensions and acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissues).

Recommended Dilution:
Immunohistochemistry: 1:20
Flow Cytometry: 1:50

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20C or colder. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG2b5F242Supernatant
SizeStorageShippingSourceHost
500ul-20CBlue IceHumanMouse
Concentration:
Not determined
Immunogen:
Human lung resistance-related protein (LRP).
Purity:
Culture supernatant
Form
Supplied as a liquid in PBS, 1% BSA, 0.1% sodium azide.
Specificity:
Reacts with an internal epitope of LRP/Major Vault Protein (P110), which is strongly overexpressed in various human non-P-glycoprotein multidrug-resistance (MDR) tumor cell lines. Not applicable in immunoblot. Species Crossreactivity: Human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Izquierdo et al. Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am J Pathol 148: 877-887 (1996)
Izquierdo MA et al. Proc Am Assoc Cancer Res 36, 323 (1995)
Schadendorf D et al. Am J Pathol 147, 1545-1552 (1995)
Scheffer GL et al. Proc Am Assoc Cancer Res 36, 323 (1995)
Scheper RJ et al. Proc Am Ass Can Res 35: 344 (1994)
Izquierdo MA et al. Proc Am Assoc Cancer Res 34, 311 (1993)
List AF et al. Blood 82, 443a (1993)
Scheper RJ et al. Cancer Research 53: 1475-1479 (1993)