Technical Data
M3890-02L
b2Microglobulin, aa21-119, Recombinant, Human (B2M, Beta 2 Microglobulin Precursor, Beta Chain of MHC Class 1 Proteins, HDCMA22P)
10ug
Molecular Biology Storage: -20CShipping: Blue Ice
Beta2 microglobulin, also known as B2M, is a component of MHC class I molecules, Involved in the presentation of peptide antigens to the immune system. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. This increase is seen in people with cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma. Multiple myeloma is a malignancy (cancer) of a certain kind of white blood cell, called a plasma cell. B2M Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease.

Source:
Recombinant corresponding to aa21-119 of human B2M 6x his tagged expressed in E.coli.

AA Sequence:
MGSSHHHHHH SSGLVPRGSH MIQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
14kD
Source: E.coli
Purity: ~95% (SDS-PAGE)
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 20% glycerol, 2mM DTT, 100mM sodium chloride.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Huang WC., et al (2010) J Biol Chem. 285(11):7947-56 2. Morabito A., et al. (2009) Hum Immunol. 70(7):492-5.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.