Technical Data
M4300-01
Moesin
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Technical Data |
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M4300-01 |
Moesin |
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Description: Moesin, a member of the talin-4 superfamily, is localized just beneath the plasma membrane and is believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. The ERM proteins, ezrin, radixin and moesin, are involved in a variety of cellular functions, such as cell adhesion, migration and the organization of cell surface structures. They are highly homologous, both in protein sequence and in functional activity with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: Frozen Optimal working dilutions to be determined by researcher. Recommended Positive Control Tissue: Human Tonsil Recommended Secondary Antibody: I1904-65W: IgG, F(ab’)2 (HRP) Pab Rb x Mo I1904-14C: IgG, Fc (HRP) Pab Gt x Mo Hybridoma: AG8 myeloma cells with spleen cells from BALB/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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