Technical Data
M4688-18C
MDR Protein (MRP1, Multidrug resistance-associated protein 1, ABCC1, ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter)
Description:
The MRP molecule, an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein, is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumors. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.

Cellular Localization: Membrane

Applications:
Suitable for use in Immunofluorescence and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG18L797Affinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
~2.08mg/ml
Immunogen:
Recombinant peptide (a.a. 1-33) of human MRP1. Epitope: Amino acids 8-17 of human MRP1.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
Specificity:
This antibody is specific for MRP1 protein. Species Crossreactivity: This antibody reacts with human and mouse. Other species have not been tested.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.