Technical Data
M4700-11C
Mucin 1 (MUC1 Glycoprotein, CD227)
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Technical Data |
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M4700-11C |
Mucin 1 (MUC1 Glycoprotein, CD227) |
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Description: Mucins are heavily glycosylated glycoproteins, which constitute the major components of mucus which cover the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. Muc-5AC and Muc-6 glycoproteins are the first two mucins found in superficial epithelium and Muc-6 glycoprotein is found in the deep glands. Belongs to monoclonal cluster 1-4 according to ISOMB TD-4 classification. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Frozen tissue sections or formalin fixed paraffin wax embedded tissue sections. Note: HIER (Microwave, citrate buffer pH 6.0) may be advantageous for some applications. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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