Technical Data
M4700-24B
MUC2 (Mucin-2, MUC-2, Intestinal Mucin-2, SMUC)
Description:
MUC-type mucins comprise a family of structurally related high molecular weight (>200kD) glycoproteins that are expressed in different epithelia that are in close contact with the milieu. Because of their large size and very complex structure, containing very extensive O-glycosylation, MUC-type mucins are difficult to study by conventional techniques. Mucins are seen as protective molecules; however, functional studies are scarce. MUC2 is an intestinal apomucin also known as intestinal MRP (Mucin Related Protein) antigen. It is expressed in mucinous tumors but not in serous tumors. Expression of MUC-2 is found in a low percentage of borderline malignancies and in ~55% of carcinomas that also express MUC1.

Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG1996/1Affinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to human MUC2.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
Specificity:
Recognizes human MUC2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.