Technical Data
M4701-85B
MUC13 (Mucin-13, MUC-13, Down-regulated in Colon Cancer 1, DRCC1, RECC, UNQ6194/PRO20221)
Description:
Mucin 13, epithelial transmembrane. SEA is an extracellular domain associated with O-glycosylation. Proteins found to contain SEA-modules include, agrin, enterokinase, 63kD sea urchin (Strongylocentrotus purpuratus) sperm protein, perlecan (heparan sulphate proteoglycan core, mucin 1 and the cell surface antigen, 114/A10, and two functionally uncharacterised, probably extracellular, Caenorhabditis elegans proteins. Despite the functional diversity of these adhesive proteins, a common denominator seems to be their existence in heavily glycosylated environments. In addition, the better characterized proteins all contain O-glycosidic-linked carbohydrates such as heparan sulphate that contribute considerably to their molecular masses. The common module might regulate or assist binding to neighboring carbohydrate moieties. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa44-58 (DTTETNFPETASTTA) of human MUC13.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity:
Recognizes human MUC13.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Williams,S.J., Wreschner,D.H., Tran,M., Eyre,H.J., Sutherland,G.R. and McGuckin,M.A. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J. Biol. Chem. 276 (21), 18327-18336 (2001).