		Technical Data
M9580-16E	Mycophenolic Acid (Melbex, Lilly 68618, NSC 129185)	25mg

Biochemicals

Storage: -20°CShipping: Blue Ice

Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation has shown mycophenolic acid to display a broad range of pharmacological activities including antitumor, antiviral, antifungal and antiprotozoan activities. However, it was the discovery that mycophenolic acid was a potent immunosuppressant, useful to prevent kidney transplant rejection, that led to its commercial development and that of related semi-synthetics as pharmaceuticals. Mycophenolic acid acts by inihibition of inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in the proliferation of B and T lymphocytes.

Source: Penicillium sp. MST-FP1988

Apperance: White solid

Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
24280-93-1

Molecular Formula:
C17H20O6

Molecular Weight:
320.3

Source: Penicillium sp. MST-FP1988
Purity: ~99%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

1. Studies in the biochemistry of micro-organisms. The molecular constitution of the metabolic products of Penicillium brevi-compactum Dierckx and related species. II. Mycophenolic acid. Clutterbuck P.W. & Raistrick H., Biochem J. 1933, 27, 654. 2. Mycophenolic acid: An anti-cancer compound with unusual properties. Carter S. B. et al., Nature 1969, 223, 848. 3. Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. Nimmesgern E. et al., J. Biol. Chem. 1996, 271, 19421.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.