Technical Data
M9755-10Q
MyD88 (Myeloid Differentiation Primary Response Protein MyD88)
Description:
Myeloid differentiation primary response protein MyD88 is a protein which in human is encoded by the MyD88 gene. MyD88 is a universal adaptor protein which interacts with all TLRs (except TLR3) and interleukin-1 receptors (IL-1Rs) to activate the transcription factor NF-kB. Functional studies show that MyD88 is involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response and acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Studies suggested that MyD88-dependent TLRs and IL-1Rs are essential for protective immunity to a limited number of pyogenic bacteria and enhance the host defense to most natural infections like common viral infections.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 2-4ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa50-100 of human MyD88.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human MyD88. Species Crossreactivity: mouse. Species sequence homology: chimpanzee, equine, orangutan, rhesus monkey.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. von Bernuth, H. et al. Science 321:691-696 (2008). 2. Arancibia, S.A. et al. Biol. Res. 40:97-112 (2007).