		Technical Data
M9755-10Q	MyD88 (Myeloid Differentiation Primary Response Protein MyD88)

Description:
Myeloid differentiation primary response protein MyD88 is a protein which in human is encoded by the MyD88 gene. MyD88 is a universal adaptor protein which interacts with all TLRs (except TLR3) and interleukin-1 receptors (IL-1Rs) to activate the transcription factor NF-kB. Functional studies show that MyD88 is involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response and acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Studies suggested that MyD88-dependent TLRs and IL-1Rs are essential for protective immunity to a limited number of pyogenic bacteria and enhance the host defense to most natural infections like common viral infections.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 2-4ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to aa50-100 of human MyD88.

Purity:

Purified by Protein A affinity chromatography.

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

Specificity:

Recognizes human MyD88. Species Crossreactivity: mouse. Species sequence homology: chimpanzee, equine, orangutan, rhesus monkey.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. von Bernuth, H. et al. Science 321:691-696 (2008). 2. Arancibia, S.A. et al. Biol. Res. 40:97-112 (2007).