Technical Data
M9758-01G1
MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein)
Description:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) found in bone marrow and the immune system may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.

Applications:
Suitable for use in ELISA, Western Blot, RIA and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a12Supernatant
SizeStorageShippingSourceHost
50ul-20CBlue IceBovineRat
Concentration:
Not determined
Immunogen:
Bovine MBP (aa82-87)
Purity:
Supernatant
Form
Supplied as a liquid, 0.09% sodium azide.
Specificity:
Reacts with bovine myelin basic protein from a wide range of species. Reacts weakly with peptides ending in the Phe 91 where the 91-92 Phe-Phe bond is broken. Species sequence homology: chicken, guinea pig, human, mammal, mouse, porcine, rabbit, rat and sheep.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.