Technical Data
M9758-01G1
MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein)
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Technical Data |
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M9758-01G1 |
MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein) |
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Description: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) found in bone marrow and the immune system may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Applications: Suitable for use in ELISA, Western Blot, RIA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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