Technical Data
M9758-08Q
MOG (Myelin-oligodendrocyte Glycoprotein)
Description:
Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). MOG protein constitutes only 0.01-0.5% of the CNS myelin proteins, has mass of 27kD, and is located in the outermost layer of myelin sheath. Human MOG is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to human MOG has been observed in induced experimental autoimmune encephalomyelitis (EAE) in C57/BL6 mice, Lewis and DA rats.

Applications:
Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-2ug/ml
Immunoprecipitation: 3-5ug/extract from 10e7 cells
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
~0.1mg/ml
Immunogen:
Recombinant corresponding to the extracellular domain of human MOG.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Specificity:
Recognizes human MOG. Species Crossreactivity: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Linares, D. et al. Prot. Expr. and Purif. 34, 249 (2004). 2. Oliver, AR. et al J. Immunol. 171, 462 (2003). 3. Von Budingen, H-C. et al. J. Clin. Imm.21, 155 (2001).