Technical Data
M9758-08R
MOG (Myelin-oligodendrocyte Glycoprotein)
Description:
Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). MOG protein constitutes only 0.01-0.5% of the CNS myelin proteins, has mass of 27kD, and is located in the outermost layer of myelin sheath. Mouse MOG is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to mouse MOG has been observed in induced experimental autoimmune encephalomyelitis (EAE) in C57/BL6, 129/Sv, B6, and SJL mice .

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceMouseRabbit
Concentration:
~0.1mg/ml
Immunogen:
Recombinant corresponding to the extracellular domain of mouse MOG.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Specificity:
Recognizes mouse MOG. Species Crossreactivity: human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Linares, D. et al. Prot. Expr. and Purif. 34, 249 (2004). 2. Bettadapura, J. et al. J. Neurochem. 70, 1593 (1998). 3. Oliver, AR. et al J. Immunol. 171, 462 (2003). 4. Von Budingen, H-C. et al. J. Clin. Imm.21, 155 (2001). 5. Lyons, J-A. et.al. Eur. J. Immunol. 29, 3432 (1999). 6. Von Budingen, H-C. et.al. Eur. J. Immunol. 34, 2072 (2003).