Technical Data
M9875B
Myostatin Fusion Protein, Recombinant, Human (Lyophilized) (Growth Differentiation Factor 8, MSTN, gdf8)
2ug
10ug
10ug
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Technical Data |
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M9875B |
Myostatin Fusion Protein, Recombinant, Human (Lyophilized) (Growth Differentiation Factor 8, MSTN, gdf8) |
2ug 10ug |
| Growth Factors, Cytokines | Storage: -20°CShipping: Blue Ice |
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Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant Human myostatin is a 25kD protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond. Biological Activity: Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17-25ng/ml. AA Sequence: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with acetic acid. Add carrier protein for long term storage. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
Source: E. coli Purity: 98% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug). Form: Supplied as a lyophilized powder. Reconstitute in sterile 10mM Acetic acid to 0.1-1.0mg/ml. Do not vortex. Add carrier protein for long term storage Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Gerard Y., Hober D., Petitjean S., Assicot M., Bohuon C., Mouton Y. & Wattre P.: High serum procalcitonin level in 4-year-old liver transplant recipient with a disseminated candidiasis. Infection 23., 310–311 (1995) 2. Assicot M., Gendrel D., Carsin H., Raimond J., Guilbaud J. & Bohuon C.: High serum calcitonin concentrations in patients with sepsis and infection. Lancet 341, 515–518 (1993)
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