Technical Data
M9931-20
Myriocin (Thermozymocidin, ISP)
2.5mg
Biochemicals Storage: -20CShipping: Blue Ice
Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.

Source: Mycelia sterilia (fungus)

Apperance: Off-white to grey powder

Solubility: Slightly soluble in DMSO, alcohols.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
35891-70-4

Molecular Formula:
C21H39NO6

Molecular Weight:
401.5
Source: Mycelia sterilia
Purity: ~97%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot.1972, 25,109. 2. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/ myriocin. Miyake Y. et al., Biochem. Biophys. Res. Commun. 1995, 211, 396. 3. Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2- hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al., J. Biol. Chem. 2005, 280, 10284.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.