Technical Data
M9931-20
Myriocin (Thermozymocidin, ISP)
2.5mg
|
Technical Data |
|
M9931-20 |
Myriocin (Thermozymocidin, ISP) |
2.5mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
|
Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant. Source: Mycelia sterilia (fungus) Apperance: Off-white to grey powder Solubility: Slightly soluble in DMSO, alcohols. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CAS Number: 35891-70-4 Molecular Formula: C21H39NO6 Molecular Weight: 401.5 |
Source: Mycelia sterilia Purity: ~97% Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
|
1. Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot.1972, 25,109. 2. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/ myriocin. Miyake Y. et al., Biochem. Biophys. Res. Commun. 1995, 211, 396. 3. Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2- hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al., J. Biol. Chem. 2005, 280, 10284.
|
||