Technical Data
N0018-69A
NALP8 (NACHT, LRR and PYD Domains-containing Protein 8, Nucleotide-binding Oligomerization Domain Protein 16, PYRIN and NACHT-containing Protein 4, NLRP8, NOD16, PAN4)
Description:
NALP8, like other NALP proteins, is a cytoplasmic protein that forms a subfamily within the larger CATERPILLER protein family. NALP8 is a short NALP, with an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. Though the exact function of NALP8 is yet unknown reports suggest that it may be involved in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa130-147 PEDLNVGETQVNLEEGES of human NALP8.
Purity:
Serum
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human NALP8. Species Crossreactivity: chimpanzee. Species sequence homology: monkey.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003). 2. Ponsuksili, S. et al. Biol Reprod. 74:577-584 (2006).